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Aβ(42) induced MRI changes in aged rabbit brain resembles AD brain.

Ramesh, B. N. and Raichurkar, K. P. and Shamasundar, N. M. and Rao, T. S. S. (2011) Aβ(42) induced MRI changes in aged rabbit brain resembles AD brain. Neurochemistry International , 59. pp. 637-642.

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Abstract

Alzheimer’s disease is the most common form of dementia and is structurally characterized by brain atrophy and loss of brain volume. Ab is one of the widely accepted causative factors of AD. Ab deposition is positively correlated with brain atrophy in AD. In the present study, structural brain imaging techniques such as Magnetic Resonance Imaging (MRI) were used to measure neuroanatomical alterations in Alzheimer’s disease brain. MRI is a non-invasive method to study brain structure. The objective of the present study was to elucidate the role of Ab on brain structure in the aged rabbit brain. Among 20 aged rabbits, one batch (n = 10) rabbits was injected chronically with Ab(1–42) and another batch (n = 10) with saline. The MRI was conducted before Ab(1–42)/saline injection and after 45 days of Ab(1–42)/saline injection. All the aged rabbits underwent MRI analysis and were euthanized after 45 days. The MRI results showed a significant reduction in thickness of frontal lobe, hippocampus, midbrain, temporal lobe and increases in the lateral ventricle volume. We also conducted an MRI study on AD (n = 10) and normal (n = 10) cases and analyzed for the thicknesses of frontal lobe, hippocampus, midbrain, temporal lobe and lateral ventricle lobe. We found significant reductions in thickness of the frontal lobe and the hippocampus. However, no significant reduction in the thickness of midbrain, temporal lobe or increase in the lateral ventricle volume was observed compared to normal. Correlations in brain atrophy changes between rabbit brain and human AD brain were found for frontal lobe and hippocampal regions. In contrast, other regions such as midbrain, temporal lobe, and lateral ventricles were not correlated with rabbit brain atrophy changes in the corresponding regions. The relevance of these changes in AD is discussed.

Item Type: Article
Uncontrolled Keywords: Beta-amyloid, Brain atrophy, Frontal cortex, Hippocampus Ventricles, Temporal lobe
Subjects: 600 Technology > 01 Medical sciences > 02 Anatomy
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 13 Feb 2012 09:05
Last Modified: 30 Dec 2016 11:05
URI: http://ir.cftri.com/id/eprint/10616

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