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Hepatoprotective and Antioxidant Effect of Fenugreek (Trigonella Foenum-Graecum) Seeds in Mice under Lithogenic Condition.

Raghunatha Reddy, R. L. and Srinivasan, Krishnapura (2011) Hepatoprotective and Antioxidant Effect of Fenugreek (Trigonella Foenum-Graecum) Seeds in Mice under Lithogenic Condition. Journal of Food Biochemistry, 35. pp. 1619-1626. ISSN 1745-4514

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Abstract

We recently reported that dietary fenugreek seeds lower the incidence of cholesterol gallstones (CGS) in high-cholesterol fed mice and also regress pre-established CGS. In this study, fenugreek was evaluated for hepatoprotective and antioxidant influence in mice fed high-cholesterol diet (HCD). After feeding HCD for 10 weeks, groups of animals were maintained for further 10 weeks on HCD/basal diet/basal diet containing 6 or 12% fenugreek. Activities of serum aspartate aminotrasferase, alanine aminotransferase, lactate dehydrogenase and alkaline phosphatase increased with prolonged feeding of HCD. Activities of these enzymes were lower in animals fed basal control/ fenugreek containing diets after initial exposure to HCD, and were prominent in fenugreek groups. Hepatic lipid peroxides decreased and antioxidant molecules increased in fenugreek fed groups. Activities of hepatic antioxidant enzymes – glutathione reductase, glutathione-Stransferase and glutathione peroxidase were higher in fenugreek treatment. These results suggested hepatoprotective and antioxidant potential of fenugreek seeds under conditions of lithogenicity.

Item Type: Article
Uncontrolled Keywords: dietary fenugreek seeds, hepatoprotective, antioxidant, health benefit
Subjects: 600 Technology > 08 Food technology > 30 Spices/Condiments
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 27 Jan 2012 03:59
Last Modified: 30 Dec 2016 08:24
URI: http://ir.cftri.com/id/eprint/10582

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