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Antioxidant and lipid peroxidation activities in rats fed with Aspergillus carbonarius carotenoid.

Anbarasu, K. and Akshatha, Hosahalli Srikanta and Muthukumar, S. P. and Umesh Kumar, S. and Vijayalakshmi, G. (2011) Antioxidant and lipid peroxidation activities in rats fed with Aspergillus carbonarius carotenoid. Food and Chemical Toxicology, 49 . pp. 3098-3103.

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Effect of feeding partially saturated canthaxanthin (PSC), purified from Aspergillus carbonarius mutant, was studied using four groups of female albino rats (n = 6) for four weeks. While the control group received basal diet ad libitum, , Groups I, II and III were fed with basal diet containing 50, 100 and 250 ppm PSC, respectively. PSC feeding did not cause any significant changes in food intake and there was no gain in body weight either. PSC included in the diet significantly decreased cholesterol in blood. There was 44.75% and 60.54% decrease in LDL-cholesterol in rats fed with 50 and 100 ppm carotenoid. Hepatic ascorbic acid content increased by 44.59% in rats fed with 50 ppm PSC. Dietary PSC at 250 ppm lowered lipid peroxides by 19.49%. Activities of antioxidant enzymes, glutathione transferase and catalase were significantly higher in serum and liver of PSC fed rats compared to the controls. The results suggested that PSC feeding can induce hypocholesterolmic and antioxidant properties in rats.

Item Type: Article
Uncontrolled Keywords: Aspergillus, Canthaxanthin, Antioxidant,HDL/LDL Rats
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 04 Fungi
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Dept. of Biochemistry
Food Microbiology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 20 Jan 2012 05:38
Last Modified: 28 Dec 2016 08:41
URI: http://ir.cftri.com/id/eprint/10536

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