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Antioxidant effect of red mould rice in hypercholesterolemic Wistar male rats.

Mohan Kumari, H. P. and Mohan, A. Dhale and Akhilender Naidu, K. and Vijayalakshmi, G. (2011) Antioxidant effect of red mould rice in hypercholesterolemic Wistar male rats. Cell Biochemistry and Function, 29. pp. 597-602.

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Abstract

The effect of Monascus purpureus red mould rice (RMR) on modulation of lipid metabolism and oxidative stress was studied in hypercholesterolemic rats. Cholesterol feeding for 14weeks caused a significant increase in the lipid peroxides and total thiols and antioxidant enzymes, viz. glutathione peroxidase (GPx), glutathione reductase (GRd), superoxide dismutase (SOD) and catalase (CAT) in serum and liver in comparison to the control group. However, supplementation of RMR to hypercholesterolemic rats at 8, 12 and 16% significantly increased the GRd, GPx, SOD and CAT activities in serum and liver tissues. Furthermore, RMR feeding significantly decreased total thiols and lipid peroxides and also increased other antioxidant molecules such as glutathione and ascorbic acid in high-cholesterol fed rats. The efficiency of RMR (16%) in modulating the antioxidant molecules and antioxidant enzymes is comparable to standard drug— lovastatin. Thus, this study suggests that the long-term administration of RMR may play an important role in suppressing oxidative stress and, thus, may be useful for the prevention and/or early treatment of hypercholesterolemia.

Item Type: Article
Uncontrolled Keywords: Monascus purpureus; red mould rice; antioxidant activity; hypercholesterolemia
Subjects: 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
600 Technology > 08 Food technology > 21 Cereals > 01 Rice
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Dept. of Biochemistry
Food Microbiology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 19 Jan 2012 04:23
Last Modified: 22 Dec 2016 13:08
URI: http://ir.cftri.com/id/eprint/10512

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