[feed] Atom [feed] RSS 1.0 [feed] RSS 2.0

Novel N-Substituted Thiazolidinones as Proton Pump Inhibitors and Potent Anti-Ulcer Agents: SAR Study.

Chandrappa, S. and Vinaya, K. and Srikanta, B. M. and Ananda Kumar, C. S. (2009) Novel N-Substituted Thiazolidinones as Proton Pump Inhibitors and Potent Anti-Ulcer Agents: SAR Study. Letters in Drug Design & Discovery , 6 (2).

Full text not available from this repository.

Abstract

A series of N-substituted thiazolidinone derivatives 5(a-j) was synthesized in good yield. All the compounds were screened for their in vitro H+, K+- ATPase inhibitory activity. The structures of the synthesized compounds were confirmed by the spectral data. Compounds 5d, 5e, 5f and 5c showed potential H+, K+- ATPase blocking activities, when compared to standard drug Lansoprazole. Structure-activity relationship studies, with various chemical groups, revealed that position and nature of the substitution on the N-thiazolidinones are crucial for H+, K+- ATPase inhibitory activity.

Item Type: Article
Uncontrolled Keywords: Anti-Ulcer Agents; thiazolidinone derivatives
Subjects: 600 Technology > 01 Medical sciences > 15 Pharmacology
500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 24 Organic Chemistry
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 09 Aug 2011 07:03
Last Modified: 09 Aug 2011 07:03
URI: http://ir.cftri.com/id/eprint/10436

Actions (login required)

View Item View Item