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Antipoliferative and apoptotic effect of ascorbyl strearate in human glioblastoma multifame cells; Modulations of insulin like growth factor receptor expression

Tang, J. L. and Naidu, K. A. and N'Aosia, S. V. and Coppola, D. (2001) Antipoliferative and apoptotic effect of ascorbyl strearate in human glioblastoma multifame cells; Modulations of insulin like growth factor receptor expression. Journal of Neuro Oncology, 54 (1). pp. 15-22.

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Abstract

Human glioblastomas (gliomas) are characterized as highly invasive and rapidly growing brain tumors. In this study, we present data on in vitro effect of ascorbyl stearate (Asc-S), a liphophilic derivative of ascorbic acid on cell proliferation, transformation, apoptosis and modulation of expression of insulin-like growth factor-I receptor (IGF-IR) in human glioblastoma multiforme (T98G) cells. Asc-S showed significant inhibition of fetal bovine serum and human recombinant insulin-like growth factor-I (IGF-I) dependent cell proliferation in a dose dependent manner. Treatment of T98G cells with 0, 50, 100 and 150 μM Asc-S for 24 h slowed down the cell multiplication cycle with significant accumulation of cells at late S/G2-M phase of cycle. Asc-S treatment (100 μM) reversed the transformed phenotype as determined by clonogenecity in soft agar and also induced apoptosis of T98G. These changes were found to be associated with significant decrease in IGF-IR expression in dose and time dependent manner compared to untreated controls. The data clearly demonstrate that Asc-S has antiproliferative and apoptotic effect on T98G cells probably through modulation of IGF-IR expression and consequent facilitation of programmed cell death.

Item Type: Article
Uncontrolled Keywords: ascorbyl stearate, glioblastoma multiforme cells, cell proliferation, insulin-like growth factor-I receptor, cell cycle, apoptosis
Subjects: 600 Technology > 01 Medical sciences
Divisions: Dept. of Biochemistry
Depositing User: Somashekar K.S
Date Deposited: 14 Jun 2011 04:25
Last Modified: 30 Jun 2015 05:40
URI: http://ir.cftri.com/id/eprint/10101

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